{"product_id":"elk-es1335-igf-ir-phospho-tyr1165-y1166-rabbit-pab","title":"IGF-IR (phospho Tyr1165\/Y1166) rabbit pAb","description":"\u003cp\u003eIGF-IR (phospho Tyr1165\/Y1166) rabbit pAb is an ELK Biotechnology antibody for research workflows involving IGF-1R.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-IGF-IR (Y1165\/Y1166) Polyclonal Antibody detects endogenous levels of IGF-IR protein only when phosphorylated at Y1165\/Y1166.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using Phospho-IGF-IR (Y1165\/Y1166) Polyclonal Antibody diluted at 1:500 | Western Blot analysis of COS7 cells using Phospho-IGF-IR (Y1165\/Y1166) Polyclonal Antibody diluted at 1:500 | Western blot analysis of lysates from 293 cells treated with Insulin, using IGF1R (Phospho-Tyr1165\/Tyr1166) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56185383977300,"sku":"ABM104527","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56185384010068,"sku":"ABM94663","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES1335-c-1.jpg?v=1782034339","url":"https:\/\/www.abmium.com\/products\/elk-es1335-igf-ir-phospho-tyr1165-y1166-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}