{"product_id":"elk-es1324-hdac5-phospho-ser498-rabbit-pab","title":"HDAC5 (phospho Ser498) rabbit pAb","description":"\u003cp\u003eHDAC5 (phospho Ser498) rabbit pAb is an ELK Biotechnology antibody for research workflows involving HDAC5.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eHistones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation\/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase\/acuc\/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-HDAC5 (S498) Polyclonal Antibody detects endogenous levels of HDAC5 protein only when phosphorylated at S498.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using Phospho-HDAC5 (S498) Polyclonal Antibody diluted at 1:500 | Western Blot analysis of VEC cells using Phospho-HDAC5 (S498) Polyclonal Antibody diluted at 1:500 | Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using HDAC5 (Phospho-Ser498) Antibody. The picture on the right is blocked with the phospho peptide. | Western blot analysis of lysates from Jurkat cells, using HDAC5 (Phospho-Ser498) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56185314083156,"sku":"ABM104462","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56185314115924,"sku":"ABM94598","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES1324-c-1.jpg?v=1782033916","url":"https:\/\/www.abmium.com\/products\/elk-es1324-hdac5-phospho-ser498-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}