{"product_id":"elk-es1323-hdac4-phospho-ser632-rabbit-pab","title":"HDAC4 (phospho Ser632) rabbit pAb","description":"\u003cp\u003eHDAC4 (phospho Ser632) rabbit pAb is an ELK Biotechnology antibody for research workflows involving HDAC4.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eHistones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation\/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase\/acuc\/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-HDAC4 (S632) Polyclonal Antibody detects endogenous levels of HDAC4 protein only when phosphorylated at S632.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using Phospho-HDAC4 (S632) Polyclonal Antibody diluted at 1:1000 | Western blot analysis of HELA SH-SY5Y 3T3 lysis using Phospho-HDAC4 (S632) antibody. Antibody was diluted at 1:1000 | Western blot analysis of lysates from 293 cells treated with etoposide 25uM 1hour and Jurkat cells treated with etoposide 25uM 24hours, using HDAC4 (Phospho-Ser632) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56185309954388,"sku":"ABM104451","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56185309987156,"sku":"ABM94587","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES1323-c-1.jpg?v=1782034325","url":"https:\/\/www.abmium.com\/products\/elk-es1323-hdac4-phospho-ser632-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}