{"product_id":"elk-es1285-cdk1-2-3-phospho-thr14-rabbit-pab","title":"Cdk1\/2\/3 (phospho Thr14) rabbit pAb","description":"\u003cp\u003eCdk1\/2\/3 (phospho Thr14) rabbit pAb is an ELK Biotechnology antibody for research workflows involving CDK1\/CDC2.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003ecyclin dependent kinase 1(CDK1) Homo sapiens The protein encoded by this gene is a member of the Ser\/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1\/S and G2\/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-Cdk1\/2\/3 (T14) Polyclonal Antibody detects endogenous levels of Cdk1\/2\/3 protein only when phosphorylated at T14.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using Phospho-Cdk1\/2\/3 (T14) Polyclonal Antibody diluted at 1:2000 | Western Blot analysis of COS7 cells using Phospho-Cdk1\/2\/3 (T14) Polyclonal Antibody diluted at 1:2000 | Immunofluorescence analysis of COS7 cells, using CDK1\/CDC2 (Phospho-Thr14) Antibody. The picture on the right is blocked with the phospho peptide. | Western blot analysis of lysates from HepG2 cells treated with Forskolin 40nM 30', using CDK1\/CDC2 (Phospho-Thr14) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56185251987796,"sku":"ABM104219","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56185252020564,"sku":"ABM94355","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES1285-c-1.jpg?v=1782033270","url":"https:\/\/www.abmium.com\/products\/elk-es1285-cdk1-2-3-phospho-thr14-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}