{"product_id":"elk-es1279-caveolin-1-phospho-tyr14-rabbit-pab","title":"Caveolin-1 (phospho Tyr14) rabbit pAb","description":"\u003cp\u003eCaveolin-1 (phospho Tyr14) rabbit pAb is an ELK Biotechnology antibody for research workflows involving Caveolin-1.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42\/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003ePhospho-Caveolin-1 (Y14) Polyclonal Antibody detects endogenous levels of Caveolin-1 protein only when phosphorylated at Y14.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using Phospho-Caveolin-1 (Y14) Polyclonal Antibody diluted at 1:1000 | Western Blot analysis of HeLa cells using Phospho-Caveolin-1 (Y14) Polyclonal Antibody diluted at 1:1000 | Western blot analysis of lysates from HUVEC cells treated with PMA 125ng\/ml 30' and HeLa cells treated with LPS 100ng\/ml 30', using Caveolin-1 (Phospho-Tyr14) Antibody. The lane on the right is blocked with the phospho peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56185244320084,"sku":"ABM104178","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56185244352852,"sku":"ABM94314","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES1279-c-1.jpg?v=1782033161","url":"https:\/\/www.abmium.com\/products\/elk-es1279-caveolin-1-phospho-tyr14-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}