{"product_id":"elk-es1063-cleaved-integrin-alpha6-lc-e942-rabbit-pab","title":"Cleaved-Integrin α6 LC (E942) rabbit pAb","description":"\u003cp\u003eCleaved-Integrin α6 LC (E942) rabbit pAb is an ELK Biotechnology antibody for research workflows involving Integrin α6.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eintegrin subunit alpha 6(ITGA6) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2\/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eCleaved-Integrin α6 LC (E942) Polyclonal Antibody detects endogenous levels of fragment of activated Integrin α6 LC protein resulting from cleavage adjacent to E942.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using Cleaved-Integrin α6 LC (E942) Polyclonal Antibody | Western blot analysis of lysates from HeLa cells, treated with etoposide 25uM 24h, using ITGA6 (light chain,Cleaved-Glu942) Antibody. The lane on the right is blocked with the synthesized peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56184944394580,"sku":"ABM102825","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56184944427348,"sku":"ABM92961","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES1063-c-1.jpg?v=1782028080","url":"https:\/\/www.abmium.com\/products\/elk-es1063-cleaved-integrin-alpha6-lc-e942-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}