{"product_id":"elk-es1049-cleaved-mmp-3-f100-rabbit-pab","title":"Cleaved-MMP-3 (F100) rabbit pAb","description":"\u003cp\u003eCleaved-MMP-3 (F100) rabbit pAb is an ELK Biotechnology antibody for research workflows involving MMP-3.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003ematrix metallopeptidase 3(MMP3) Homo sapiens Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eCleaved-MMP-3 (F100) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-3 protein resulting from cleavage adjacent to F100.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using Cleaved-MMP-3 (F100) Polyclonal Antibody | Western blot analysis of lysates from A549, 293, and HeLa cells, treated with etoposide 25uM 24h, using MMP3 (Cleaved-Phe100) Antibody. The lane on the right is blocked with the synthesized peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56184933220692,"sku":"ABM102744","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56184933253460,"sku":"ABM92880","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES1049-c-1.jpg?v=1782028055","url":"https:\/\/www.abmium.com\/products\/elk-es1049-cleaved-mmp-3-f100-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}