{"product_id":"elk-es1026-cleaved-cathepsin-d-hc-l169-rabbit-pab","title":"Cleaved-Cathepsin D HC (L169) rabbit pAb","description":"\u003cp\u003eCleaved-Cathepsin D HC (L169) rabbit pAb is an ELK Biotechnology antibody for research workflows involving Cathepsin D.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eCleaved-Cathepsin D HC (L169) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin D HC protein resulting from cleavage adjacent to L169.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using Cleaved-Cathepsin D HC (L169) Polyclonal Antibody | Western blot analysis of lysates from 293, A549, and JurKat cells, treated with etoposide 25uM 1h, using CATD (heavy chain,Cleaved-Leu169) Antibody. The lane on the right is blocked with the synthesized peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56184916181332,"sku":"ABM102620","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56184916214100,"sku":"ABM92756","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES1026-c-1.jpg?v=1782027662","url":"https:\/\/www.abmium.com\/products\/elk-es1026-cleaved-cathepsin-d-hc-l169-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}