{"product_id":"elk-es1025-cleaved-cathepsin-c-hc-r394-rabbit-pab","title":"Cleaved-Cathepsin C HC (R394) rabbit pAb","description":"\u003cp\u003eCleaved-Cathepsin C HC (R394) rabbit pAb is an ELK Biotechnology antibody for research workflows involving Cathepsin C HC.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015],\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecificity\u003c\/th\u003e\n\u003ctd\u003eCleaved-Cathepsin C HC (R394) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin C HC protein resulting from cleavage adjacent to R394.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern Blot analysis of various cells using Cleaved-Cathepsin C HC (R394) Polyclonal Antibody | Western blot analysis of lysates from Jurkat cells, treated with etoposide 25uM 1h, using Dipeptidyl-peptidase 1 (heavy chain,Cleaved-Arg394) Antibody. The lane on the right is blocked with the synthesized peptide.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56184915362132,"sku":"ABM102615","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56184915394900,"sku":"ABM92751","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/ES1025-c-1.jpg?v=1782027592","url":"https:\/\/www.abmium.com\/products\/elk-es1025-cleaved-cathepsin-c-hc-r394-rabbit-pab","provider":"ABMIUM","version":"1.0","type":"link"}