{"product_id":"elk-ept141-recombinant-human-trail","title":"Recombinant Human TRAIL","description":"\u003cp\u003eRecombinant Human TRAIL is an ELK Biotechnology recombinant protein for research use.\u003c\/p\u003e\u003ch3\u003eDescription\u003c\/h3\u003e\u003cp\u003eRecombinant Human TNF-Related Apoptosis-Inducing Ligand is produced by our E.coli expression system and the target gene encoding Arg115-Gly281 is expressed.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eHuman TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2\/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.\u003c\/p\u003e\u003ch3\u003eHandling information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\u003ctr\u003e\n\u003cth\u003eDelivery condition\u003c\/th\u003e\n\u003ctd\u003eThe product is shipped on dry ice\/polar packs. Upon receipt, store it immediately at the temperature listed below.\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"10ug","offer_id":56187605320020,"sku":"ABM100865","price":88.0,"currency_code":"GBP","in_stock":true}],"url":"https:\/\/www.abmium.com\/products\/elk-ept141-recombinant-human-trail","provider":"ABMIUM","version":"1.0","type":"link"}