{"product_id":"elk-em1145-cleaved-parp-mouse-mab","title":"Cleaved PARP Mouse mAb","description":"\u003cp\u003eCleaved PARP Mouse mAb is an ELK Biotechnology antibody for research workflows involving Cleaved PARP.\u003c\/p\u003e\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003ePoly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate.\u003c\/p\u003e\u003ch3\u003eAdditional antibody information\u003c\/h3\u003e\u003ctable\u003e\u003ctbody\u003e\u003ctr\u003e\n\u003cth\u003eValidation evidence captions\u003c\/th\u003e\n\u003ctd\u003eWestern blot analysis of Jurkat with EM1145 diluted at 1:2,000. | Immunohistochemical analysis of paraffin-embedded human Tonsil Tissue using Cleaved PARP （EM1145）Mouse mAb diluted at 1:500.\u003c\/td\u003e\n\u003c\/tr\u003e\u003c\/tbody\u003e\u003c\/table\u003e","brand":"ELK Biotechnology","offers":[{"title":"Unconjugated \/ 100µL","offer_id":56184870764884,"sku":"ABM102343","price":220.41,"currency_code":"GBP","in_stock":true},{"title":"Unconjugated \/ 50µL","offer_id":56184870797652,"sku":"ABM92479","price":131.54,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/EM1145-c-1.jpg?v=1782026908","url":"https:\/\/www.abmium.com\/products\/elk-em1145-cleaved-parp-mouse-mab","provider":"ABMIUM","version":"1.0","type":"link"}