{"product_id":"abm221877","title":"Recombinant Human IL-15 protein","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eHuman Interleukin-15 (IL-15) is expressed by the IL15 gene located on the chromosome 4. It shares approximately 97 % and 73 % sequence identity with simian and Mouse IL-15, respectively. Both human IL-15 and simian IL-15 are active on Mouse cells. IL-15 is secreted by mononuclear phagocytes (and some other cells), especially macrophages following infection by virus. It possesses a variety of biological functions, including stimulating and maintaining of cellular immune responses, especially regulating T and natural killer (NK) cell activation and proliferation. In additionally, it shares many biological properties with IL-2, including T, B and NK cell-stimulatory activities. IL-15 signals through a complex composed of IL-2\/IL-15 receptor beta chain. Although IL-15 lacks sequence homology with IL-2, it has recently been shown that both the beta and gamma chains of the IL-2 receptor are utilized for IL-15 binding and signaling. In addition, an IL-15 specific binding protein has also been cloned from a mouse T cell clone.\u003c\/p\u003e\u003cdl\u003e\n\u003cdt\u003eExpression system\u003c\/dt\u003e\n\u003cdd\u003eEscherichia coli.\u003c\/dd\u003e\n\u003cdt\u003ePurity\u003c\/dt\u003e\n\u003cdd\u003e\u0026gt; 97 % by SDS-PAGE and HPLC analyses.\u003c\/dd\u003e\n\u003cdt\u003eMolecular weight\u003c\/dt\u003e\n\u003cdd\u003eApproximately 12.9 kDa, a single non-glycosylated polypeptide chain containing 114 amino acids.\u003c\/dd\u003e\n\u003cdt\u003eEndotoxin\u003c\/dt\u003e\n\u003cdd\u003eLess than 1EU\/μg of rHuIL-15 as determined by LAL method.\u003c\/dd\u003e\n\u003cdt\u003eForm\u003c\/dt\u003e\n\u003cdd\u003eSterile Filtered White lyophilized (freeze-dried) powder. Formulation Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.\u003c\/dd\u003e\n\u003c\/dl\u003e\u003cp\u003e\u003cem\u003ePackaging image shown for reference. Select a size from the available options.\u003c\/em\u003e\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"10 ug","offer_id":57661669802324,"sku":"ABM221877","price":262.0,"currency_code":"GBP","in_stock":true},{"title":"2 ug","offer_id":57661669835092,"sku":"ABM221878","price":113.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-0fd1f6372ffcfb473d60291b19ad3a3c1ba873bf34f64149b8c025ca5826680b.jpg?v=1792159240","url":"https:\/\/www.abmium.com\/products\/abm221877","provider":"ABMIUM","version":"1.0","type":"link"}