{"product_id":"abm218830","title":"Human Calsyntenin 1, CLSTN1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eInduces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661595451732,"sku":"ABM218830","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661595484500,"sku":"ABM218831","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-eefab1b23f8a39dedec59b4535f0b5dffead6972b5aa4acd7bda59bd16257f25.jpg?v=1792159238","url":"https:\/\/www.abmium.com\/products\/abm218830","provider":"ABMIUM","version":"1.0","type":"link"}