{"product_id":"abm218796","title":"Human Ubiquitin-like-conjugating Enzyme Atg3, ATG3 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eE2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57662036771156,"sku":"ABM218796","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57662036803924,"sku":"ABM218797","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-3aa1209655cd80114bc49ba5efd65927014bbe4c0cfbb25fdb1660e5ec0668c6.jpg?v=1792159235","url":"https:\/\/www.abmium.com\/products\/abm218796","provider":"ABMIUM","version":"1.0","type":"link"}