{"product_id":"abm218774","title":"Human C-X-C Chemokine Receptor Type 3, CXCR3 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003e[Isoform 1]: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed: 12782716). Binds to CCL21. Probably promotes cell chemotaxis response. [Isoform 2]: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed: 12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. [Isoform 3]: Mediates the activity of CXCL11.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57662022648148,"sku":"ABM218774","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57662022680916,"sku":"ABM218775","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-942b9e850054576b4f8bb884aab83191d9f1510f576a82e49323e45a92c62b21.jpg?v=1792159234","url":"https:\/\/www.abmium.com\/products\/abm218774","provider":"ABMIUM","version":"1.0","type":"link"}