{"product_id":"abm218498","title":"Human Peptidyl-prolyl Cis-Trans Isomerase D, CYCLOPHILIN-40 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003ePPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661822959956,"sku":"ABM218498","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661822992724,"sku":"ABM218499","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-922d7c445b31e1ea225b5ffe656c5fcea116b4f9edc62b4fd0dd312a195c617b.jpg?v=1792159216","url":"https:\/\/www.abmium.com\/products\/abm218498","provider":"ABMIUM","version":"1.0","type":"link"}