{"product_id":"abm218248","title":"Human Cholesterol Side-chain Cleavage Enzyme, CYP11A1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eA cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (PubMed:21636783). Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (PubMed:21636783). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin\/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin\/ferredoxin) (PubMed:21636783).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661639262548,"sku":"ABM218248","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661639295316,"sku":"ABM218249","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-c6fdd14177c172efcc1dd211f808218f25e95e0dc0eabbd5a381b7a455f39718.jpg?v=1792159248","url":"https:\/\/www.abmium.com\/products\/abm218248","provider":"ABMIUM","version":"1.0","type":"link"}