{"product_id":"abm217374","title":"Human Presenilin 1, PS-1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCatalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed: 15274632, PubMed: 10545183, PubMed: 10593990, PubMed: 10206644, PubMed: 10899933, PubMed: 10811883, PubMed: 12679784, PubMed: 12740439, PubMed: 25043039, PubMed: 26280335, PubMed: 30598546, PubMed: 30630874, PubMed: 28269784, PubMed: 20460383). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed: 15274632, PubMed: 25043039, PubMed: 26280335, PubMed: 30598546, PubMed: 30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed: 9738936, PubMed: 10593990, PubMed: 10899933, PubMed: 10811883). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed: 11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed: 11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed: 9738936, PubMed: 11953314). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2\/CTF1 into EphB2\/CTF2 (PubMed: 17428795, PubMed: 28269784). The holoprotein functions as a calcium-leak Channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed: 25394380, PubMed: 16959576). Involved in the regulation of neurite outgrowth (PubMed: 15004326, PubMed: 20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661943742804,"sku":"ABM217374","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661943775572,"sku":"ABM217375","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-9330653ad0e103d426ef4982f38df1fdd590ad09cdb35c93777e4531c30dabdd.jpg?v=1792159235","url":"https:\/\/www.abmium.com\/products\/abm217374","provider":"ABMIUM","version":"1.0","type":"link"}