{"product_id":"abm217228","title":"Human Nucleotide-binding Oligomerization Domain-containing Protein 2, NOD2 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eInvolved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed: 18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed: 20637199). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling\/MAVS, leading to activation of interferon regulatory factor-3\/IRF3 and expression of type I interferon (PubMed: 19701189).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661834625364,"sku":"ABM217228","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661834658132,"sku":"ABM217229","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-bda60fbbea549b619f1239d69011231cf6ca7e9c144f44d600bb3c91fb339f47.jpg?v=1792159224","url":"https:\/\/www.abmium.com\/products\/abm217228","provider":"ABMIUM","version":"1.0","type":"link"}