{"product_id":"abm217100","title":"Human Myeloid Cell Surface Antigen Cd33, CD33 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eSialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed: 10611343, PubMed: 15597323, PubMed: 11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed: 7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed: 28325905, PubMed: 10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6\/SHP-1 and PTPN11\/SHP-2 (PubMed: 10556798, PubMed: 10206955, PubMed: 10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed: 10206955, PubMed: 10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase\/PI3K (PubMed: 15597323).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661740122452,"sku":"ABM217100","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661740155220,"sku":"ABM217101","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-4e4fef1484f3f5138f4ce20aff2a6015a9cbdc6aa92d674f2d806d3f7abd88db.jpg?v=1792159214","url":"https:\/\/www.abmium.com\/products\/abm217100","provider":"ABMIUM","version":"1.0","type":"link"}