{"product_id":"abm216948","title":"Human Lysine-specific Demethylase 5A, KDM5A ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eHistone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL\/BMAL1-mediated transcriptional activation of PER1\/2 and other clock-controlled genes and increases histone acetylation at PER1\/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661629563220,"sku":"ABM216948","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661629595988,"sku":"ABM216949","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-025d2119baa9a3c49808e5d40e3acac7dc82c7122562d660660be63a4b5a9dcb.jpg?v=1792159203","url":"https:\/\/www.abmium.com\/products\/abm216948","provider":"ABMIUM","version":"1.0","type":"link"}