{"product_id":"abm216402","title":"Human Eyes Absent Homolog 2, EYA2 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eFunctions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed: 12500905, PubMed: 23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed: 19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed: 12500905).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661720691028,"sku":"ABM216402","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661720723796,"sku":"ABM216403","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-4628ea1589a3f5686063e024ac3c112b668cdefde96edfc01780b55f47dde242.jpg?v=1792159214","url":"https:\/\/www.abmium.com\/products\/abm216402","provider":"ABMIUM","version":"1.0","type":"link"}