{"product_id":"abm214002","title":"Human Interleukin 1 Receptor Accessory Protein, IL1RAP ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCoreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor\/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). [Isoform 2]: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted\/soluble receptors (PubMed: 12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity). [Isoform 4]: Unable to mediate canonical IL-1 signaling (PubMed: 19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661836460372,"sku":"ABM214002","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661836493140,"sku":"ABM214003","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-4065fbe1ac2f4fc134cb94faf00366750fc40f38e4e79d79bce93e2fa3fe80c1.jpg?v=1792159245","url":"https:\/\/www.abmium.com\/products\/abm214002","provider":"ABMIUM","version":"1.0","type":"link"}