{"product_id":"abm213736","title":"Human Transmembrane Protease, Serine 2, TMPRSS2 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003ePlasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed: 25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor\/HGF, the protease activated receptor-2\/F2RL1 or matriptase\/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed: 15537383, PubMed: 26018085, PubMed: 25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed: 24227843, PubMed: 32142651, PubMed: 32404436). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661638181204,"sku":"ABM213736","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661638213972,"sku":"ABM213737","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-6e8ed2f415f01b8741a442ef02f6a9f57f3ef7fcba1f6a3518c525906296ba7c.jpg?v=1792159225","url":"https:\/\/www.abmium.com\/products\/abm213736","provider":"ABMIUM","version":"1.0","type":"link"}