{"product_id":"abm213680","title":"Rat Serine, Threonine-protein Kinase Tao2, TAOK2 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eSerine\/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14\/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14\/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2\/M transition DNA damage checkpoint by activating the p38\/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14\/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14\/p38 MAPK activation.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661596336468,"sku":"ABM213680","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661596369236,"sku":"ABM213681","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-3a9de9ff205e006534860230c68a63231769a4f6630de2f40e78aa7a37667ede.jpg?v=1792159221","url":"https:\/\/www.abmium.com\/products\/abm213680","provider":"ABMIUM","version":"1.0","type":"link"}