{"product_id":"abm213550","title":"Human Sorting Nexin 9, SNX9 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eInvolved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and\/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57662014849364,"sku":"ABM213550","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57662014882132,"sku":"ABM213551","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1ca195aa81426053c23a72ee85c8cc8f6fd5696b4b8811ee8a4423d033f5bcce.jpg?v=1792159211","url":"https:\/\/www.abmium.com\/products\/abm213550","provider":"ABMIUM","version":"1.0","type":"link"}