{"product_id":"abm213164","title":"Mouse R-spondin-1, RSPO1 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eActivator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes (PubMed: 21693646). Also regulates the canonical Wnt\/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination (By similarity). Regulates Wnt signaling by antagonizing DKK1\/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661706797396,"sku":"ABM213164","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661706830164,"sku":"ABM213165","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-dc5111065c1e65c81ef81381404e217d815a7a6b8c4c6cff941c7e26b30f30dc.jpg?v=1792159232","url":"https:\/\/www.abmium.com\/products\/abm213164","provider":"ABMIUM","version":"1.0","type":"link"}