{"product_id":"abm210792","title":"Human Progranulin, PGRN ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eSecreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed: 28541286, PubMed: 28073925, PubMed: 18378771, PubMed: 28453791, PubMed: 12526812). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (PubMed: 28453791, PubMed: 28541286). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed: 28073925). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed: 12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed: 18378771). [Granulin-4]: Promotes proliferation of the epithelial cell line A431 in culture. [Granulin-3]: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. [Granulin-7]: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661811720532,"sku":"ABM210792","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661811753300,"sku":"ABM210793","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-da168d3c3ca6ce564bd05b38cccb27ac320cfa88464455302f2fea552fc8eb9e.jpg?v=1792159209","url":"https:\/\/www.abmium.com\/products\/abm210792","provider":"ABMIUM","version":"1.0","type":"link"}