{"product_id":"abm210056","title":"Rat Cyclin-dependent Kinase 4, CDK-4 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eSer\/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)\/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB\/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D\/CDK4\/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"48T","offer_id":57661850321236,"sku":"ABM210056","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"96T","offer_id":57661850354004,"sku":"ABM210057","price":293.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-721f3e7c6f720f37f37a04ddd54fdae7635b21f7ba3bb0a87784dae6bcde20d3.jpg?v=1792159205","url":"https:\/\/www.abmium.com\/products\/abm210056","provider":"ABMIUM","version":"1.0","type":"link"}