{"product_id":"abm207372","title":"Human Interleukin 33, IL-33 ELISA Kit","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eCytokine that binds to and signals through the IL1RL1\/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed: 16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed: 17853410, PubMed: 18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB\/RELA, lowering expression of its targets (PubMed: 21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed: 18787100).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"96T","offer_id":57661022568788,"sku":"ABM207372","price":293.0,"currency_code":"GBP","in_stock":true},{"title":"48T","offer_id":57661022601556,"sku":"ABM207373","price":205.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-414544809a6bc57c0cef3833b588e505713156fdb36f3a84c4547dbf9f5cb031.jpg?v=1792159078","url":"https:\/\/www.abmium.com\/products\/abm207372","provider":"ABMIUM","version":"1.0","type":"link"}