{"product_id":"abm206618","title":"Phospho-AR (S213) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. AR contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.\u003c\/p\u003e\u003cp\u003e\u003cem\u003ePackaging image shown for reference. Select a size from the available options.\u003c\/em\u003e\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57661370990932,"sku":"ABM206618","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661371023700,"sku":"ABM206619","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661371056468,"sku":"ABM206620","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-f324e8429e766fa1531f7fd366db4d43d637484a38050b0923e08284f225198b.jpg?v=1792157294","url":"https:\/\/www.abmium.com\/products\/abm206618","provider":"ABMIUM","version":"1.0","type":"link"}