{"product_id":"abm204073","title":"TNF-alpha Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eTNF-alpha (tumor necrosis factor alpha) is an important cytokine produced by numerous cell types including neutrophils, activated lymphocytes, macrophages and NK cells. It plays a critical role in inflammatory responses and in apoptosis. TNF-alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF-alpha exists as a multimer of two, three, or five non covalently linked units, but shows a single 17 kDa band following SDS PAGE under non reducing conditions. Although it has little effect on many cultured normal human cells, TNF-alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF-alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF-alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57661313712468,"sku":"ABM204073","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57661313745236,"sku":"ABM204074","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-5fd5b75e4346b2b80750ecca6465d10b1c666b4a108fca0dafdfc930e1fe72a2.jpg?v=1792159172","url":"https:\/\/www.abmium.com\/products\/abm204073","provider":"ABMIUM","version":"1.0","type":"link"}