{"product_id":"abm203767","title":"GSK3B Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eGlycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological conditions including cancer and diabetes and is increasingly seen as an important component of neurological diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3beta are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor trafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcription factors and structural proteins, and is part of the signal transduction cascade of a large number of growth factors and cytokines. The activity of GSK is regulated by phosphorylation (Akt: Akt-mediated phosphorylation at Ser21 of GSK-3a and Ser9 of GSK-3\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57660866789716,"sku":"ABM203767","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57660866822484,"sku":"ABM203768","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-9a74987561972d39c81195186e8b05974c2799c2e5e4b6d20836335aee7a038f.jpg?v=1792159090","url":"https:\/\/www.abmium.com\/products\/abm203767","provider":"ABMIUM","version":"1.0","type":"link"}