{"product_id":"abm203721","title":"RAG2 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57660800008532,"sku":"ABM203721","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57660800041300,"sku":"ABM203722","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-c8a4e86cfbdab8305c9e00a6d1e73184718fda40045e4d65b5be0b0028adac8f.jpg?v=1792159078","url":"https:\/\/www.abmium.com\/products\/abm203721","provider":"ABMIUM","version":"1.0","type":"link"}