{"product_id":"abm203635","title":"BLNK Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57661570220372,"sku":"ABM203635","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57661570253140,"sku":"ABM203636","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1f356a99dd9f197decf08d08605db97607cbe52a77e8a2a8b6910b4a0e06cbcd.jpg?v=1792159155","url":"https:\/\/www.abmium.com\/products\/abm203635","provider":"ABMIUM","version":"1.0","type":"link"}