{"product_id":"abm203499","title":"CDKN1B Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003ep27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin\/Cdk complexes such as cyclin D1\/Cdk4. Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57661547708756,"sku":"ABM203499","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57661547741524,"sku":"ABM203500","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1cde6271af3161eec424c9d1e501c98cd36d9fede734935e270fb15cee887e2f.jpg?v=1792159119","url":"https:\/\/www.abmium.com\/products\/abm203499","provider":"ABMIUM","version":"1.0","type":"link"}