{"product_id":"abm202415","title":"RFA2 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide\/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100μL","offer_id":57661103604052,"sku":"ABM202415","price":205.0,"currency_code":"GBP","in_stock":true},{"title":"50μL","offer_id":57661103636820,"sku":"ABM202416","price":141.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-330b2435ddbea397df07a1453edd6601af5abf7a5f3348cf670e02eacda1f60e.jpg?v=1792159107","url":"https:\/\/www.abmium.com\/products\/abm202415","provider":"ABMIUM","version":"1.0","type":"link"}