{"product_id":"abm200284","title":"PEG10 Monoclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis is a paternally expressed imprinted gene that is thought to have been derived from the Ty3\/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1| and a longer, gag\/pol-like fusion protein (with an additional aspartic protease motif) from RF1\/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"50ul","offer_id":57661497606484,"sku":"ABM200284","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661497639252,"sku":"ABM200285","price":192.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-35af9dd6dc59ebbfef0a53fd5c55a7d1e54f2e80a8af1222056ddbc9853ebbf7.jpg?v=1792159011","url":"https:\/\/www.abmium.com\/products\/abm200284","provider":"ABMIUM","version":"1.0","type":"link"}