{"product_id":"abm198089","title":"FRS2(Phospho Tyr436) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eAdapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence Translated as stop.,Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57661198467412,"sku":"ABM198089","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661198500180,"sku":"ABM198090","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661198532948,"sku":"ABM198091","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-ec45b29786404e54ab29e012e3372e74bfe0bb963dfdb6e3afac3539faf68997.jpg?v=1792159007","url":"https:\/\/www.abmium.com\/products\/abm198089","provider":"ABMIUM","version":"1.0","type":"link"}