{"product_id":"abm197132","title":"E2F-1 (Acetyl-K125) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can media\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57661280289108,"sku":"ABM197132","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661280321876,"sku":"ABM197133","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661280354644,"sku":"ABM197134","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-7ed664f52f8ca1251fcc1f3b16ba7739c8303d319afc166adf81ee8abfe643be.jpg?v=1792158949","url":"https:\/\/www.abmium.com\/products\/abm197132","provider":"ABMIUM","version":"1.0","type":"link"}