{"product_id":"abm194537","title":"Bestrophin-1 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57661309747540,"sku":"ABM194537","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661309780308,"sku":"ABM194538","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661309813076,"sku":"ABM194539","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-874467fc39a7fed688ecce817b96ce4e8e2798199475ba93b7412a44126ccb92.jpg?v=1792158998","url":"https:\/\/www.abmium.com\/products\/abm194537","provider":"ABMIUM","version":"1.0","type":"link"}