{"product_id":"abm193088","title":"NFκB-p105\/p50(Phospho Ser337) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines| oxidant-free radicals| ultraviolet irradiation| and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isof\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57661089087828,"sku":"ABM193088","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661089120596,"sku":"ABM193089","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57661089153364,"sku":"ABM193090","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-75faba32adbebe2b70b5906efb2a9d10c90cb596f10756412ca1344d45a6fe3b.jpg?v=1792159045","url":"https:\/\/www.abmium.com\/products\/abm193088","provider":"ABMIUM","version":"1.0","type":"link"}