{"product_id":"abm189848","title":"Stat5(Phospho-Tyr694) Rabbit Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors| STAT family members are phosphorylated by the receptor associated kinases| and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands| such as IL2| IL4| CSF1| and different growth hormones. It has been shown to be involved in diverse biological processes| such as TCR signaling| apoptosis| adult mammary gland development| and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57661308371284,"sku":"ABM189848","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661308404052,"sku":"ABM189849","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57661308436820,"sku":"ABM189850","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1ea4c7287cbfdf5088445786c5a5187a69f59f2a2d1db38ede993084a9fd9773.jpg?v=1792241051","url":"https:\/\/www.abmium.com\/products\/abm189848","provider":"ABMIUM","version":"1.0","type":"link"}