{"product_id":"abm189290","title":"p40-phox(Phospho Thr154) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2\/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1\/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding d\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660918497620,"sku":"ABM189290","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660918530388,"sku":"ABM189291","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660918563156,"sku":"ABM189292","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-d72ffaf365e2ff521a91fd2202e6b519aaded769d1866a8cab3b37108686cfed.jpg?v=1792158980","url":"https:\/\/www.abmium.com\/products\/abm189290","provider":"ABMIUM","version":"1.0","type":"link"}