{"product_id":"abm189152","title":"p21(Phospho Thr145) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lac\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660818489684,"sku":"ABM189152","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660818522452,"sku":"ABM189153","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660818555220,"sku":"ABM189154","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-3c9dc796d9bca16882cb20e3686329fffa996d595d0554b67b9ec1041f68bc44.jpg?v=1792158968","url":"https:\/\/www.abmium.com\/products\/abm189152","provider":"ABMIUM","version":"1.0","type":"link"}