{"product_id":"abm182551","title":"HIF-1 alpha (Acetyl Lys532) Rabbit Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eContains two independent C-terminal transactivation domains| NTAD and CTAD| which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID).|Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes| including| erythropoietin| glucose transporters| glycolytic enzymes| vascular endothelial growth factor| and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization| tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"100ul","offer_id":57661216391508,"sku":"ABM182551","price":176.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57661216424276,"sku":"ABM182552","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"20ul","offer_id":57661216457044,"sku":"ABM182553","price":69.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-1ea4c7287cbfdf5088445786c5a5187a69f59f2a2d1db38ede993084a9fd9773.jpg?v=1792241051","url":"https:\/\/www.abmium.com\/products\/abm182551","provider":"ABMIUM","version":"1.0","type":"link"}