{"product_id":"abm178930","title":"TRAP230 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThe initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1. MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by the gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660335456596,"sku":"ABM178930","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660335489364,"sku":"ABM178931","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660335522132,"sku":"ABM178932","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-0903d2772e157fdd2b1b5ebf0c927df0cd1be6a07d8b77397beb61b563beaf48.jpg?v=1792158824","url":"https:\/\/www.abmium.com\/products\/abm178930","provider":"ABMIUM","version":"1.0","type":"link"}