{"product_id":"abm173401","title":"pNO40 Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eZinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZCCHC17 (zinc finger, CCHC domain containing 17), also known as PS1D (putative S1 RNA-binding domain protein), Pnn (Pinin)-interacting nucleolar protein or pNO40, is a 241 amino acid protein that associates with both Pinin and the 60S ribosomal subunit. Localizing to nucleolus, ZCCHC17 is ubiquitously expressed and has been suggested to play a role in ribosome maturation and biogenesis. ZCCHC17 contains one CCHC-type zinc finger, a S1 motif domain and exists as two alternatively spliced isoforms that map to human chromosome 1p35.2. Human chromosome 1 spans 260 million base pairs, contains over 3000 genes, comprises nearly 8% of the human genome and houses a large number of disease-associated genes, including those that are involved in Stickler syndrome, Parkinson's disease, Gaucher disease and Usher syndrome.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660694593876,"sku":"ABM173401","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660694626644,"sku":"ABM173402","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660694659412,"sku":"ABM173403","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-40813e23c8a09a83bfe9d6acf97302829a9a41a9a0985df5cc33cb532c2b523d.jpg?v=1792158895","url":"https:\/\/www.abmium.com\/products\/abm173401","provider":"ABMIUM","version":"1.0","type":"link"}