{"product_id":"abm169513","title":"Abl1(Phospho Tyr204) Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eThis gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes| including cell division| adhesion| differentiation| and response to stress. The activity of the protein is negatively regulated by its SH3 domain| whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation| suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias| most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants| which contain alternative first exons that are spliced to the remaining common exons.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57660454666580,"sku":"ABM169513","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57660454699348,"sku":"ABM169514","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57660454732116,"sku":"ABM169515","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-18c22085747b3c40a931ea8c8b26eeb254b400f8aa948fbe8ddb14cc1b5f008e.jpg?v=1792158847","url":"https:\/\/www.abmium.com\/products\/abm169513","provider":"ABMIUM","version":"1.0","type":"link"}