{"product_id":"abm165187","title":"IL-4R Alpha Polyclonal Antibody","description":"\u003ch3\u003eBackground\u003c\/h3\u003e\u003cp\u003eIL4R encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. Interleukin-4 receptor subunit alpha also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"20ul","offer_id":57659896004948,"sku":"ABM165187","price":69.0,"currency_code":"GBP","in_stock":true},{"title":"50ul","offer_id":57659896037716,"sku":"ABM165188","price":115.0,"currency_code":"GBP","in_stock":true},{"title":"100ul","offer_id":57659896070484,"sku":"ABM165189","price":176.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1782\/2036\/files\/btlab-33a6f85b7cf178adef55517ea3adc20153dcdef05b9231f699387d78f07b6c39.jpg?v=1792158818","url":"https:\/\/www.abmium.com\/products\/abm165187","provider":"ABMIUM","version":"1.0","type":"link"}